Vaccine breakthrough means no more chasing strains

 

Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.

 

Every year, researchers try to predict the four influenza strains that are most likely to be prevalent during the upcoming flu season. And every year, people line up to get their updated vaccine, hoping the researchers formulated the shot correctly. The same is true of COVID vaccines, which have been reformulated to target sub-variants of the most prevalent strains circulating in the U.S.

 

This new strategy would eliminate the need to create all these different shots, because it targets a part of the viral genome that is common to all strains of a virus. The vaccine, how it works, and a demonstration of its efficacy in mice is described in a paper  published recently in the Proceedings of the National Academy of Sciences (PNAS). 

 

Read the full article at: news.ucr.edu

Gemini, a family of multimodal models demonstrating strong capabilities across image, audio, video, and text domains

 

Google has introduced a family of multimodal models, called Gemini, that exhibit remarkable capabilities across image, audio, video, and text understanding. The Gemini family consists of Ultra, Pro, and Nano sizes, suitable for applications ranging from complex reasoning tasks to on-device memory-constrained use-cases. Evaluation on a broad range of benchmarks shows that the most-capable Gemini Ultra model advances the state of the art in 30 of 32 of these benchmarks – notably being the first model to achieve human-expert performance on the well-studied exam benchmark MMLU, and improving the state of the art in every one of the 20 multimodal benchmarks we examined. Thus, Google believes that the new capabilities of the Gemini family in cross-modal reasoning and language understanding will enable a wide variety of use cases. In this article the authors discuss their approach toward post-training and deploying Gemini models responsibly to users through services including Gemini, Gemini Advanced, Google AI Studio, and Cloud Vertex AI.

 

 

See more details in Google’s Gemini technical report.

Read the full article at: arxiv.org

5 Books On AI In Education And Why You Should Read Them

Discover five must-read books on AI and ChatGPT in education, recommended by educators. These books offer practical insights and strategies to enhance teaching with AI.

I’ve read far too many books on ChatGPT and artificial intelligence.

Almost all of them are a waste of time when it comes to applying them to education.

But, there are five books educators on LinkedIn, X (formerly Twitter) and Facebook have recommended. And it’s these five books I recommend to every educator exploring AI.

Read the full article at: www.forbes.com

How generative AI could fix Siri, Alexa, and hopefully Google Assistant, too

By enabling abilities like context and natural conversation, generative AI technology could bring us actually useful digital assistants.

Voice assistants hold so much promise, but in the decade-plus since Apple’s Siri and Amazon’s Alexa first wormed their ways into our lives, their most compelling use is still setting timers. Competition from Google’s Assistant (and if we’re being charitable, Samsung’s Bixby) failed to light the spark of innovation in this space, and in many ways, voice control has regressed. These assistants regularly misunderstand, mishear, and sometimes just don’t listen at all. They’re a far cry from the proactive, actually smart digital assistants they were originally pitched as.

Read the full article at: www.theverge.com

COVID can cause new health problems even 3 years after infection, new study finds

 

A new report reinforces that the virus is not going away. Even as national institutions struggle to coordinate meaningful trials for possible long COVID treatments, researchers continue to tally the damage. New findings suggest that the disease’s reach isn’t merely long—it’s still growing. Three years after their initial bouts with COVID-19, patients who’d once been hospitalized with the virus remained at “significantly elevated” risk of death or worsening health from long COVID complications, according to a paper published May 30, 2024 in Nature Medicine. Even among those whose initial cases didn’t require a hospital stay, the threat of long COVID and several of its associated issues remained real, the researchers found. And cumulatively, at three years, long COVID results in 91 disability-adjusted life years (DALY) per 1,000 people—DALYs being a measure of years lost to poor health or premature death. That is a higher incidence than either heart disease or cancer.

 

 
Published in Nat. Medicine (May 30 2024):
 

Read the full article at: fortune.com

The Once-In-An-Eon Event That Gave Earth Plants Has Happened Again

The first-ever nitrogen-fixing organelle in a eukaryotic cell has been confirmed.

An event that is only known to have happened three times before in the history of life on Earth has just been documented again. A marine bacterium was subsumed into its algal host organism, co-evolving with it for long enough that it can now be considered an organelle, part of the alga’s cellular machinery. That means these algae are the first eukaryotes (organisms with their DNA in a membrane-bound nucleus) known to contain an organelle capable of fixing nitrogen.

“It’s very rare that organelles arise from these types of things,” said Tyler Coale, first author of one of two recent papers on the discovery, in a statement.

“Very rare” could actually be considered an understatement. The first time this happened – as far as we know – it gave rise to the very first complex life by birthing mitochondria. Since then, it’s happened twice more, including over a billion years ago, marking the dawn of plant life on Earth by giving us the chloroplast.

The groundwork for the latest finding was laid almost 30 years ago, when a team led by UC Santa Cruz Professor Jonathan Zehr discovered a new cyanobacterium in the Pacific Ocean with the ability to fix nitrogen. That’s the process by which microbes pull free nitrogen from the environment and combine it with other elements to form new nitrogen compounds, like the fertilizers that are essential for life to thrive.

Read the full article at: www.iflscience.com

Parasitoid Wasps Use Viruses as Biological Weapons

 

To protect and rear their young, some insects have transformed wild viruses into tiny biological weapons. If you puncture the ovary of a wasp called Microplitis demolitor, viruses squirt out in vast quantities, shimmering like iridescent blue toothpaste. “It’s very beautiful, and just amazing that there’s so much virus made in there,” says Gaelen Burke, an entomologist at the University of Georgia. M. demolitor  is a parasite that lays its eggs in caterpillars, and the particles in its ovaries are “domesticated” viruses that have been tuned to persist harmlessly in wasps and serve their purposes. The virus particles are injected into the caterpillar through the wasp’s stinger, along with the wasp’s own eggs. The viruses then dump their contents into the caterpillar’s cells, delivering genes that are unlike those in a normal virus. Those genes suppress the caterpillar’s immune system and control its development, turning it into a harmless nursery for the wasp’s young.

 

The insect world is full of species of parasitic wasps that spend their infancy eating other insects alive. And for reasons that scientists don’t fully understand, they have repeatedly adopted and tamed wild, disease-causing viruses and turned them into biological weapons. Half a dozen examples already are described, and new research hints at many more. By studying viruses at different stages of domestication, researchers today are untangling how the process unfolds.

Read the full article at: knowablemagazine.org

Mixing tradition with technology: The emergence of AI in bartending

In the vibrant world of bartending, where every cocktail tells a story and every mix is an art, a new chapter is being stirred by Artificial Intelligence (AI). This isn’t a tale of machines replacing the human touch but one where technology and tradition blend to create a new era of mixology. From AI recommendations to robotic bartenders, this blog explores how AI is not just changing the way drinks are served but is enriching the very essence of bartending.

Bartending, a craft that combines skill, creativity, and an understanding of flavors, is embracing AI, not as a replacement but as a complement. AI in bartending isn’t about removing the bartender; it’s about enhancing their capabilities and offering them new ways to delight their patrons. Consider, while there is a wide assortment of drink recipes, bartenders find more and more patrons are looking for unusual, or at least specialized, drinks based on their individual palettes. This ranges not just on the type of alcohol but the level of sweetness, bitterness, peatyness, etc. In essence, people want a strong level of individual taste presences for their drinks.

Read the full article at: www.forbes.com