Scientists Use CRISPR to Make Chickens More Resistant to Bird Flu

 

A new study highlights both the promise and the limitations of gene editing, as a highly lethal form of avian influenza continues to spread around the world.

 

Scientists have used the gene-editing technology known as CRISPR to create chickens that have some resistance to avian influenza, according to a new study that was published in the journal Nature Communications on Tuesday. The study suggests that genetic engineering could potentially be one tool for reducing the toll of bird flu, a group of viruses that pose grave dangers to both animals and humans. But the study also highlights the limitations and potential risks of the approach, scientists said. Some breakthrough infections still occurred, especially when gene-edited chickens were exposed to very high doses of the virus, the researchers found. And when the scientists edited just one chicken gene, the virus quickly adapted.

 

The findings suggest that creating flu-resistant chickens will require editing multiple genes and that scientists will need to proceed carefully to avoid driving further evolution of the virus, the study’s authors said. The research is “proof of concept that we can move toward making chickens resistant to the virus,” Wendy Barclay, a virologist at Imperial College London and an author of the study, said at a news briefing. “But we’re not there yet.” Some scientists who were not involved in the research had a different takeaway. “It’s an excellent study,” said Dr. Carol Cardona, an expert on bird flu and avian health at the University of Minnesota. But to Dr. Cardona, the results illustrate how difficult it will be to engineer a chicken that can stay a step ahead of the flu, a virus known for its ability to evolve swiftly. “There’s no such thing as an easy button for influenza,” Dr. Cardona said. “It replicates quickly, and it adapts quickly.”

What to Know About Avian Flu

The spread of H5N1. A new variant of this strain of the avian flu has spread widely through bird populations in recent years. It has taken an unusually heavy toll on wild birds and repeatedly spilled over into mammals, including minks, foxes and bears.

 

 

Research cited published in Nature Comm. (Oct. 10, 2023):

https://doi.org/10.1038/s41467-023-41476-3 

Read the full article at: www.nytimes.com

The Future of AI is Here: Cerebras’ WSE-2 is the largest computer chip ever built and the fastest AI processor on Earth

 

Cluster-Scale Performance on a Single Large-Wafer Chip

Programming a cluster to scale deep learning is painful. It typically requires dozens to hundreds of engineering hours and remains a practical barrier for many to realize the value of large-scale AI for their work. On a traditional GPU cluster, ML researchers – typically using a special version of their ML framework – must figure out how to distribute their model while still achieving some fraction of their convergence and performance target. They must navigate the complex hierarchy of individual processors’ memory capacity, bandwidth, interconnect topology, and synchronization; all while performing a myriad of hyper-parameter and tuning experiments along the way. What’s worse is that the resultant implementation is brittle to change, and this time only delays overall time to solution. With the WSE, there is no bottleneck. We give you a cluster-scale AI compute resource with the programming ease of a single desktop machine using stock TensorFlow or PyTorch. Spend your time in AI discovery, not cluster engineering.

Learn more

 

 

Designed for AI
 

Each core on the WSE is independently programmable and optimized for the tensor-based, sparse linear algebra operations that underpin neural network training and inference for deep learning, enabling it to deliver maximum performance, efficiency, and flexibility. The WSE-2 packs 850,000 of these cores onto a single processor. With that, and any data scientist can run state-of-the-art AI models and explore innovative algorithmic techniques at record speed and scale, without ever touching distributed scaling complexities.

 

1000x Memory Capacity and Bandwidth

 

Unlike traditional devices, in which the working cache memory is tiny, the WSE-2 takes 40GB of super-fast on-chip SRAM and spreads it evenly across the entire surface of the chip. This gives every core single-clock-cycle access to fast memory at extremely high bandwidth – 20 PB/s. This is 1,000x more capacity and 9,800x greater bandwidth than the leading GPU. This means no trade-off is required. You can run large, state-of-the art models and real-world datasets entirely on a single chip. Minimize wall clock training time and achieve real-time inference within latency budgets, even for large models and datasets.

220Pb/s

 

 
High Bandwidth – Low Latency
 

Deep learning requires massive communication bandwidth between the layers of a neural network. The WSE uses an innovative high bandwidth, low latency communication fabric that connects processing elements on the wafer at tremendous speed and power efficiency. Dataflow traffic patterns between cores and across the wafer are fully configurable in software. The WSE-2 on-wafer interconnect eliminates the communication slowdown and inefficiencies of connecting hundreds of small devices via wires and cables. It delivers an incredible 220 Pb/s processor-processor interconnect bandwidth. That’s more than 45,000x the bandwidth delivered between graphics processors.

Read the full article at: www.cerebras.net

The Ethics of AI in Content Creation: Balancing Automation with Originality

With recent developments in generative AI, the question of ethical content creation and the use of human-made content has come into question. And while the generative AI industry is still in its infancy, many companies must take measures to balance automation with original high-quality content.

It’s still very early to tell which direction the generative AI industry will take and what limitations will be placed on generative AI platforms. So for now, companies using this technology are the ones responsible for guaranteeing ethical use and protecting the rights of content creators. Here is how some companies can find a balance between automation and originality.

 

Learn more / En savoir plus / Mehr erfahren:

 

https://gustmees.wordpress.com/?s=curation

 

https://gustmees.wordpress.com/?s=blogging

 

https://globaleducationandsocialmedia.wordpress.com/2014/01/19/pkm-personal-professional-knowledge-management/

 

https://www.scoop.it/topic/21st-century-learning-and-teaching/?&tag=Blogging

 

https://www.scoop.it/topic/21st-century-learning-and-teaching/?&tag=content+marketing

 

https://www.scoop.it/topic/21st-century-learning-and-teaching/?&tag=SEO

 

 

Read the full article at: blog.scoop.it

Pioneers of mRNA COVID Vaccines Win Nobel Prize for Medicine

 

Katalin Karikó and Drew Weissman laid the groundwork for immunizations that were rolled out during the pandemic at record-breaking speed. This year’s Nobel Prize in Physiology or Medicine has been awarded to biochemist Katalin Karikó and immunologist Drew Weissman for discoveries that enabled the development of mRNA vaccines against COVID-19. The vaccines have been administered more than 13 billion times, saved millions of lives and prevented millions of cases of severe COVID-19, said the Nobel committee. Karikó, who is at Szeged University in Hungary, and Weissman, at the University of Pennsylvania in Philadelphia (UPenn), paved the way for the vaccines’ development by finding a way to deliver genetic material called messenger RNA into cells without triggering an unwanted immune response. They will each receive an equal share of the prize, which totals 11 million Swedish krona (US$1 million). Karikó is the 13th female scientist to win a Nobel Prize in medicine or physiology. She was born in Hungary, and moved to the United States in the 1980s. “Hopefully, this prize will inspire women and immigrants and all of the young ones to persevere and be resilient. That’s what I hope,” she tells Nature.

 

https://doi.org/10.1038/d41586-023-03046-x

Read the full article at: www.nature.com