A new way to manufacture small batches of biopharmaceuticals on demand using Pichia pastoris

MIT researchers have developed a new way to rapidly manufacture biopharmaceuticals on demand. Their system can be easily reconfigured to produce different drugs, enabling flexible switching between products as they are needed. "Traditional biomanufacturing relies on unique processes for each new molecule that is produced," says J. Christopher Love, a professor of chemical engineering at MIT and a member of MIT’s Koch Institute for Integrative Cancer Research. "We’ve demonstrated a single hardware configuration that can produce different recombinant proteins in a fully automated, hands-free manner."


The researchers have used this manufacturing system, which can fit on a lab benchtop, to produce three different biopharmaceuticals, and showed that they are of comparable quality to commercially available versions. Love is the senior author of the study, which appears in the October 1, 2018 issue of the journal Nature Biotechnology.



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